Protein Details: Potassium channel subfamily K member 1
Protein ID
ICDB_Pro_0176
Protein Name
Potassium channel subfamily K member 1
Gene Name
Kcnk1
Organism
Mus musculus (Mouse)
Length
336 amino acids
AlphaFoldDB
AF-O08581-F1-model_v4.pdb
Function
Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes; but also in kidney and in other tissues. Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH; but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium. The homodimer has very low potassium channel activity; when expressed in heterologous systems; and can function as weakly inward rectifying potassium channel. Channel activity is modulated by activation of serotonin receptors. Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity; and may represent the predominant form in astrocytes. Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity. Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (By similarity). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential. Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability. In astrocytes; the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors; such as F2R and CNR1. Required for normal ion and water transport in the kidney. Contributes to the regulation of the resting membrane potential of pancreatic beta cells. The low channel activity of homodimeric KCNK1 may be due to sumoylation. The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes.
Sequence
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Detected in spiral ganglion neurons (PubMed:17079103). Detected in hippocampus CA1 and CA1 regions and in the molecular layer of the dentate gyrus (PubMed:24368895; PubMed:25406588). Detected on hippocampus astrocytes (PubMed:24368895; PubMed:24496152). Detected on hippocampus astrocytes (PubMed:24368895; PubMed:24496152). Detected on hippocampus astrocytes (PubMed:24368895; PubMed:24496152). Highly expressed in the stria vascularis in the cochlea (PubMed:12855359). Detected in pancreas islet beta cells (PubMed:22431633). Detected in kidney; at brush border membranes in proximal tubules and in cytoplasmic structures in distal convoluted tubules; thick ascending limbs and collecting ducts (at protein level) (PubMed:15540117; PubMed:16025300). Widely expressed. Detected in spiral ganglion cells (PubMed:17079103). Highest expression in brain; kidney; thyroid; salivary gland; adrenal gland; prostate; epididymis; uterus; placenta; colon and jejunum. Moderate expression in eyes; pituitary; pancreas; smooth muscle; testis and ovary. Very low levels in lung; aorta; liver; heart; skeletal muscle; thymus and spleen. In the brain; highest expression in cerebellar granule cells; brainstem; hippocampus and cerebral cortex (PubMed:18222039)
DOI ID
10.1016/s0014-5793(96)01491-3; 10.1016/s0014-5793(98)00260-9; 10.1101/gr.2596504; 10.1016/s0378-5955(03)00162-x; 10.1038/sj.embor.7400292; 10.1007/s00424-005-1480-9; 10.1007/s00424-006-0107-0; 10.1016/j.heares.2006.09.002; 10.1016/j.neuroscience.2007.12.011; 10.1016/j.cell.2010.12.001; 10.1074/jbc.m109.078535; 10.1073/pnas.1201132109; 10.3389/fncel.2013.00246; 10.1113/jphysiol.2014.287268; 10.1186/s13041-014-0080-z; 10.1038/ncomms4227; 10.1007/s00424-014-1631-y
RefSeq
NP_032456.2